Tiny gold bars latest rage for jittery investors | Gold Anti-Trust Action ...

By Oliver Hirt
Reuters
Friday, December 21, 2012

http://www.reuters.com/article/2012/12/21/swiss-gold-idUSL5E8NL4N8201212...

ZURICH, Switzerland -- Private investors in Switzerland, Austria, and Germany are lining up to buy gold bars the size of a credit card that can easily be broken into 1-gram pieces and used as payment in an emergency.

Now Swiss refinery Valcambi, a unit of U.S. mining giant Newmont, wants to bring its "CombiBar" to market in the United States and build up its sales presence India, the world's largest consumer of gold, where the precious metal has long served as a parallel currency.

Investors worried that inflation and financial market turmoil will wipe out the value of their cash have poured money into gold over the past decade. Prices have gained almost 500 percent since 2001 compared to a 12 percent increase in MSCI's world equity index.

... Dispatch continues below ...

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Sales of gold bars and coins were worth almost $77 billion in 2011, up from just $3.5 billion in 2002, according to data from the World Gold Council.

"The rich are buying standard bars or have deposits of phsyical gold. People who have less money are buying up to 100 grams," said Michael Mesaric, CEO of Valcambi. "But for many people a pure investment product is no longer enough. They want to be able to do something with the precious metal."

Mesaric said the advantage of the "CombiBar" -- which has been dubbed a "chocolate bar" because pieces can be easily broken off by hand into one gram squares -- is that it can be easily transported and costs less than buying 50 one gram bars.

"The produce can also be used as an alternative method of payment," he said.

Valcambi is building a sales network in India and plans to launch the CombiBar on the U.S. market next year. In Japan, it wants to focus on CombiBars made of platinum and palladium.

Elsewhere, demand is particularly strong among Germans, still scarred by post-World War I hyperinflation, when money became all but worthless and it took a wheelbarrow full of notes to buy a loaf of bread.

"Above all, it's people aged between 40 and 70 that are investing in gold bars and coins," said Mesaric. "They've heard tales from their parents about wars and crises devaluing money."

The CombiBar is particularly popular among grandparents who want to give their grandchildren a strip of gold rather than a coin, said Andreas Habluetzel head of the Swiss business of Degussa, a gold trading company.

Other customers buy gold for security reasons.

"Demand is rising every week," Habluetzel said. "Particularly in Germany, people buying gold fear that the euro will break apart or that banks will run into problems."

Some fund managers, however, remain sceptical.

Stephan Mueller, who manages bank Julius Baer's $6 billion gold fund, said one problem with using gold as a method of payment is that people have to take its value on blind trust.

"Gold is a useful store of value," Mueller said. "However, I doubt whether it will succeed as a method of payment."

Nonetheless, as developments in the euro zone lurch from one crisis to another, demand for gold that can be sold in vending machines is also growing.

"Sales rise according to the temperature of the crisis," said Thomas Geissler, whose firm Ex Oriente Lux operates 17 gold vending machines in Europe, the United States and the United Arab Emirates.

The machines saw record sales in 2010, one day after the then Deutsche Bank CEO Josef Ackermann raised doubts over whether Greece would be able to pay its debts.

Since the launch of the machines, which operate under the name "GOLD to go", 50,000 customers have withdrawn more than 21 million euros in gold. The average buyer is male, over 50 years old and well off.

"Customers are hoarding gold mostly at home as a precaution against a crisis, just as their fathers and grandfathers did before them," Geissler said.

* * *

Join GATA here:

Vancouver Resource Investment Conference
Sunday-Monday, January 20 and 21, 2013
Vancouver Convention Centre West
Vancouver, British Columbia, Canada
http://www.cambridgehouse.com/event/vancouver-resource-investment-confer...

* * *

Support GATA by purchasing DVDs of our London conference in August 2011 or our Dawson City conference in August 2006:

http://www.goldrush21.com/order.html

Or by purchasing a colorful GATA T-shirt:

http://gata.org/tshirts

Or a colorful poster of GATA's full-page ad in The Wall Street Journal on January 31, 2009:

http://gata.org/node/wallstreetjournal

Help keep GATA going

GATA is a civil rights and educational organization based in the United States and tax-exempt under the U.S. Internal Revenue Code. Its e-mail dispatches are free, and you can subscribe at:

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Source: http://www.gata.org/node/12063

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On the Black List: The Relationship Between Screenwriting and ...

Theorem: every director is also a screenwriter, but not every screenwriter is a director. Here?s an extreme but exemplary anecdote. A few weeks ago, when my colleague Adam Gopnik and I introduced Vincente Minnelli?s rhapsodically beautiful Second World War romance ?The Clock? at the New-York Historical Society, we called attention to a remarkable scene?the hastily newlywed couple?s morning after at the small breakfast table in a room of a modest hotel. They have awakened from their night of love?the only one they?ll have before the groom (Robert Walker), a soldier on furlough, heads off to war?and the bride (Judy Garland) serves him coffee as they speak of their happiness, their hopes and dreams. At least, that?s how the scene (which kicks in at 5:35) was written (the script is credited to Robert Nathan and Joseph Schrank). As Minnelli describes the shoot in his autobiography, he found the dialogue fatuous, inadequate to the delicate, intimate grandeur of the moment?and instead of calling Nathan and Schrank for a rewrite or tweaking it himself, he threw the dialogue out altogether, resulting in an amazingly delicate, breath-holding sequence of more than two minutes of wordless yet profound communion. Though Minnelli didn?t put pencil to paper, he took over the function of the screenwriter by assimilating it to his directorial insights and inventions.

Similarly, Nicholas Ray threw out the scripted conclusion of ?In a Lonely Place? and, working with his stars, Humphrey Bogart and Gloria Grahame, helped them to improvise a new?and agonizingly beautiful?ending. Howard Hawks completely reshaped the script of ?Come and Get It? while his producer, Samuel Goldwyn, was away from the set due to illness. As I?ve written here before, don?t trust the credits: even when directors don?t get writing credit, they usually should, especially if the movie?s any good.

Much of directing is directing against the script, of mining it for what?s latent in it?which often means breaking it open in some essential way. Yet writing a script has become one of the most popular paths to a directorial career?and, for many directors who start this way, directing has become a way not of taking off from a script but of protecting the script. That became one of the templates for the (mediocre) independent film, and it remains so. Many of them convey the sense that a director thinks it suffices to take pictures of actors emotively embodying the written action and spouting the written dialogue to get the fullness of the story across, to make it exist. And not just independent films; that?s also the thumbnail of the worst of so-called midrange dramas, with the general difference that the director and the screenwriter are two different people but that the director, who may well have come from the land of theatre, is in love with the script and may as well paste its pages onto the screen.

Corollary: there?s no such thing as a good or bad subject. That?s why I find the Black List?s list of the year?s ??most liked?? unproduced screenplays (as published here at ComingSoon.net) frustratingly opaque. There?s no particular reason to be automatically interested in the story of ?Draft Day,? which tops the list (about a football team?s general manager who ?trades for the number one draft pick? and ?must quickly decide what he?s willing to sacrifice in pursuit of perfection as the lines between his personal and professional life become blurred?); if the script is any good, it?s in the particulars. But the danger is that, the more prized the script, the tougher for a director to lay his or her hands on it vigorously?as suggested by this apparently unintended caveat that comes along from Daniel Lehman?s post about the list at Backstage:

Past Best Picture winners ?Slumdog Millionaire? and ?The King?s Speech? and 2012 films ?Argo? and ?Looper? are among the films that were recognized by the Black List before being produced.

The moderate merits of ?Slumdog Millionaire? have little to do with the script; the lockstep rigidity of ?The King?s Speech? and ?Argo? has everything to do with their scriptiness; and, as for ?Looper,? the director Rian Johnson (who also wrote the script) came up with some good directorial choices to bring some of the script conceits to life, but, overall, got caught up in the overplotted gamesmanship of his screenplay and its science-fiction setup; he?d have done better to thresh it vigorously and trust more in his clever visual sense. Otherwise he?s at risk of making an ?Inception?-like puzzle that feels directed by word processor and bulletin board.

It?s worth noting that a preponderance of movies on the list deal with political and/or historical subjects; does this reflect what the hundreds of polled industry insiders themselves like to see, or think would do the best business, or?Oscar-style?what they think is intrinsically most worthy? There?s a movie about young Hillary Rodham, torn between Washington and Bill Clinton; one in which ?a Mossad employed father and his C.I.A. agent son team up to hunt an escaped Nazi?; one about an apparatchik in the Stalin-era Soviet Union; one set in the Civil War; one about American soldiers in Iraq; one about a German spy?s plot to kill F.D.R. during the Second World War. We?re in the middle of the year?s sludgy season?the political self-importance of the season?s Oscar-primed and critically ballyhooed frontrunners?and the sun of experience and fantasy usually breaks through the winter sky early in the new year, with films that wouldn?t be atop the Black List, that may never make it onto the Oscar ballots, but which often, at least, make it onto plenty of year-end lists. The Black List suggests, if nothing else, that the gap between Oscar-land and the year?s true worthies may be growing ever greater.

Source: http://www.newyorker.com/online/blogs/movies/2012/12/on-the-black-list-the-relationship-between-screenwriting-and-directing.html

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Customer-service call lasts 10 hours

Zappos.com

By Martha C. White

When a customer-service rep goes above and beyond to try to solve your problem, that's welcome. When they spend 10-and-a-half hours on the phone giving you advice about relocating to Las Vegas, that's Zappos.com.

Unlike many other online retailers (including parent company Amazon.com), Zappos plasters its site with its toll-free customer service number, which is staffed 24/7. When a Midwestern college student called the site's Nevada headquarters two weeks ago to buy a pair of Uggs boots, the transaction turned into a chat marathon about the city, where the student was considering moving. The rep was able to take some breaks during the call; the customer agreed to hold the line.

Zappos spokesman Jeff Lewis said providing good customer service is a top priority. "We feel that allowing our team members the ability to stay on the phone with a customer for as long as they need is a crucial means of fulfilling this value," he said via email.

By assuring management that it wouldn?t interfere with Zappos? free-spirited corporate culture when it acquired the shoe retailer in 2009, Amazon?benefits from the customer-service elements that make Zappos customers so loyal.

?Amazon has purposely allowed that culture to continue to proliferate,? said Bryan Pearson, president of LoyaltyOne, a loyalty marketing and strategy company. ?I?m sure they?re bringing some of the key lessons from the Zappos experience into Amazon."

Jordy Leiser, CEO of Stella Service, a customer service measurement and ratings business, said this is the case. In a study conducted a few months ago, Zappos tied with L.L. Bean for the best customer service on Twitter. Leiser said that when Amazon saw how much customers liked being able to solve customer service issues over the microblogging site, it started offering customer support via tweet, too. Zappos had been using Twitter to field customer queries since 2008.

"They are starting to integrate and rub off on each other," he said.?

Amazon didn't have poor customer service beforehand, according to Stella's research; it just wasn't the focus of the shopper experience.?"In online, it's about fulfillment and a smooth shopping experience," Sucharita Mulpuru, an analyst with Forrester Research, said via email.?

In this regard, Amazon delivers, Leiser said. "They please customers with their shipping and logistics experience," Leiser said. Earlier this year, Amazon took over some of Zappos' back-end inventory-management processes, letting Zappos benefit from one of its strong spots.

And both Amazon and Zappos ranked highly in Stella's survey of phone service responsiveness, with mystery shoppers able to reach live agents in about a minute, on average.

"Each of them has the things that are most important to their customer base. For Zappos, it?s all about the phone customer service," Leiser said. Apparently that service even includes a lengthy discussion about moving advice.?

More money news:

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Source: http://lifeinc.today.com/_news/2012/12/21/16069991-zappos-customer-service-call-lasts-10-hours?lite

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Welcome to Paid Surveys, Etc. ? Get Paid For Your Opinion : Internet ...

You are here: Home / General / Welcome to Paid Surveys, Etc. ? Get Paid For Your Opinion

"The CEO?s of: Walmart ? Amazon and eBay Are Tripping Over Their Own Feet To Give Me Money!" These million-dollar-a-year fat cats, don?t know squat about their customers? So they pay ?ordinary? people like me to tell them the word on the street.

Each day I help these companies make more informed decisions about what their customers really like and don?t like about specific products.

These companies spend 1.5 Billion Dollars per Month? because if they don?t know what their typical customers needs and wants are, then they won?t have a business come next season.

This is a tiny example of what?s available. There are hundreds of companies that have massive lists of potential surveys to take.

Life is not as hectic as it once was. Now I set my own hours and usually just work on my laptop in bed. It?s normal for me to make $25 ? $45 before breakfast, simply by answering a few surveys.

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Even if you have never done anything like this before, you don?t need to worry because I will show you how to start making money today.

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Y?see for a risk free trial of 60 days I?ll let you become one of my Paid Surveys, Etc. Members. You?ll be able to complete surveys free for 60 days and if you decide not to continue you won?t be charged a penny. The simple fact is if you don?t start earning and if your life doesn?t change dramatically. then I don?t want your money.

I think that?s only fair. I don?t ever want to sell a product to someone that?s not getting 100 times+ the value for what they paid me.

Read more?

Posted by Dan on Friday, December 21, 2012 at 10:11 am?
Filed under General ? Tagged with

Source: http://www.theyellowads.com/internet_businesses_online/welcome-to-paid-surveys-etc-get-paid-for-your-opinion

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Year in Science: Higgs boson takes the prize

From July 4, 2012: A group of scientists claim they've discovered a subatomic particle that closely matches the description of the fabled Higgs boson. NBC's Mara Schiavocampo reports.

By Alan Boyle

As 2012 draws to a close, physicists are celebrating ? and being celebrated for?? the end of a four-decade scientific quest to find a subatomic particle known as the Higgs boson. The discovery, made at the $10 billion Large Hadron Collider and reported in July, won honors this week as Science magazine's Breakthrough of the Year as well as a piece of the spotlight in Time magazine's Person of the Year package.

But the story of what some have nicknamed "the God particle" isn't over yet. (Physicists hate that nickname, by the way.)

"This particle has the potential to be a portal to a new landscape of physical phenomena that is still hidden from us," the scientific team behind the LHC's Compact Muon Solenoid detector writes in a Science paper that lays out the details behind the discovery.

---

That sentiment comes through as well in another paper from the LHC's ATLAS collaboration, which found results consistent with those from the CMS detector. The ATLAS scientists say finding the particle appears to provide the "last missing piece" in the Standard Model, the scientific theory that explains the subatomic realm ??but also sets the stage for further studies "to explore the physics that must lie beyond" the Standard Model.

Both teams said they detected a particle that matched the quarry they sought, with a mass in the range of 125 billion electron volts. But they haven't yet quite confirmed that its characteristics fully conform with the theoretical particle that was proposed in the 1960s to fill in the Standard Model's remaining gaps.

CERN / ATLAS Experiment

This schematic shows the pattern of subatomic particle tracks associated with a candidate event for the detection of the Higgs boson.

That particle would help explain why some fundamental particles, such as the W and Z bosons, possess mass?? while others, such as photons, don't. Physicists can see that such a mechanism must exist; otherwise, the cosmos just wouldn't work. The problem is figuring out how the mechanism is structured. The Higgs boson, and its associated Higgs field, fills the bill.

There's still some question whether the new particle reported this year is the Higgs boson, as described in the traditional Standard Model, or part of a more complex Higgs mechanism that may include other particles. Last week, there was a brief kerfuffle over whether the data from ATLAS hinted at two Higgs particles???but as of now, the leading view is that those hints are just statistical fluctuations that will eventually disappear. The definitive word is expected to come at a conference in March.

By that time, the LHC will be shut down for a major upgrade. The particle collider, housed in a 17-mile-round (27-kilometer-round) underground tunnel beneath the French-Swiss border near Geneva, has been running at energies of up to 8 trillion electron volts ? but the upgrade will allow it to operate at 13 to 14 TeV starting in 2015. That's when the really way-out discoveries, relating to mysteries such as supersymmetry or the nature of dark matter, could come to light.

Why should we care about the Higgs boson? It may not bring us a better iPhone next year ? but a better understanding of fundamental physics typically leads to better applications down the line. Just ask the inventors of medical scanners, microwave ovens or laser devices. For more on the practical implications of research at the LHC, check out our interactive interview with physicist Michio Kaku.

The same disclaimer goes for Science's runner-up breakthroughs of the year. You may not see how some of these discoveries can relate to everyday life?? but someday, you or your children will:

Unraveling the Denisovan genome: In late 2010, anthropologists used genetic tools to discover a new type of human ancestor that lived in Siberia tens of thousands of years ago, dubbed the Denisovans. This year, they used a new technique to compare the Denisovan genome with those of modern-day populations ??and confirmed that some parts of the Denisovan genetic heritage were passed on. That's right, kids: Our ancestors did it with Denisovans. The new technique is expected to yield a high-quality version of the Neanderthal genome in 2013.

Making eggs from stem cells: Japanese researchers coaxed mouse stem cells into becoming viable eggs that produce healthy offspring. There are a few caveats: The eggs still have to be hosted by an actual mouse during one stage of their maturation, and the technique doesn't yet work with human cells. But the project represents another significant step in the fight against infertility.

Curiosity's landing system: Perhaps the most amazing thing about the Curiosity rover's landing on Mars in August was that a system designed to lower the rover from a rocket-powered, hovering platform actually worked. NASA engineers acknowledged that the idea seemed crazy but insisted it was the "least crazy" way to get the 1-ton payload safely to the surface. The "sky crane" concept worked so well that NASA plans to do it again in 2020. For more about the Curiosity mission, check out our "Year in Space" roundup.

X-ray laser reveals protein structure: Scientists used intense, ultra-short X-ray pulses from a free-electron laser to collect data on the 3-D structure of proteins?? and single-shot images of an intact virus. "The grand goal is to push X-ray diffraction to its ultimate limit and use an X-ray laser to decipher a protein structure by zapping individual molecules," Science's editors write.

Precision engineering of genomes: If you haven't heard about TALENs and CRISPR yet, you will?? at least if genetic engineering is your thing. These are new tools for "editing" the genomes of creatures ranging from zebrafish to rats and crickets. Even human cells are being tweaked for research purposes. "Some researchers now think TALENs [transcription activator-like effector nucleases] will become standard procedure for all molecular biology labs," the editors say.

Majorana fermions detected, sort of: Seventy-five years ago, Italian physicist Ettore Majorana theorized that a weird type of subatomic particle existed that could act as its own antiparticle. This year, Dutch physicists reported tentative signs that the particles have at last been detected. If their existence is confirmed, Majorana fermions would have properties that make them perfectly suited for quantum computing.

ENCODE zooms in on human genome: After a decade of research, a $288 million project to trace all the threads that make up the human genome issued a blizzard of scientific papers. The studies?suggested that only a small percentage of our DNA is wrapped up in our genes. At the time, much was made of the fact that what was once called "junk DNA" plays an important role in our genetic makeup. But we knew that already, right? The important thing is that Project ENCODE ("Encyclopedia of DNA Elements") has made a grand start toward reading, and understanding, our book of life.

Better brain-machine interfaces: Is the "Star Trek" nightmare vision of the Borg coming to pass? Not yet: We are not being assimilated into machinery. But in the future, it should become easier for us to assimilate machinery when the need arises. Researchers are perfecting techniques for controlling artificial limbs, computers or other devices with our thoughts alone. Someday even physicist Stephen Hawking might benefit from mind-reading systems. ?

A new door in neutrino physics:?Researchers caught a rare type of exotic particle known as an electron antineutrino in the act of disappearing, at an experimental facility in China?? and that vanishing trick provided yet another long-sought puzzle piece in subatomic physics. The researchers said they measured the last parameter describing how different types of neutrinos morph into each other. For what it's worth, that parameter, the mixing angle known as theta13, equals 8.8 degrees, plus or minus 0.8 degrees. The fact that the value isn't zero could help explain why there's so much matter and so little antimatter in our universe.

Frontiers for 2013: In addition to 2012's breakthroughs, Science's editors highlighted six scientific areas to watch in 2013: single-cell DNA sequencing, the Planck probe's study of the cosmic microwave background, the Human Connectome Project, ultra-deep ice drilling at Antarctica's Lake Vostok, cancer immunotherapy research and basic plant research.

More about the Higgs quest:

---

Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.

Source: http://cosmiclog.nbcnews.com/_news/2012/12/20/16045777-the-year-in-science-higgs-boson-leads-2012s-list-of-breakthroughs?lite

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Another day, another non-hockey-stick: 'A new paper published in Quaternary Research reconstructs June-July air temperature over the past 785 years in British Columbia, Canada'

'The paper shows that reconstructed temperatures at the end of the record in 2010 were colder than in the 1940's and during at least 6 other periods within the Little Ice Age from 1350-1850 AD. The temperature record shows there is nothing unusual, unnatural, unprecedented, or accelerated about the 20th and 21st centuries. The reconstructed temperatures of 2010 have been exceeded many times over the past 785 years, even during the Little Ice Age'

Source: http://www.climatedepot.com/a/18864/Another-day-another-nonhockeystick-A-new-paper-published-in-Quaternary-Research-reconstructs-JuneJuly-air-temperature-over-the-past-785-years-in-British-Columbia-Canada

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Apple Releases iOS 6.0.2 Software Update For iPhone 5, iPad Mini To Fix Wi-Fi Bug [Download Links]

As Redmond Pie noted, although releasing an iOS firmware update only for a couple devices is something of a rarity for Apple, ?this is by no means an isolated incident.? Given that the Wi-Fi bug in question seems only to affect the iPhone 5 and the iPad mini, owners of either of those new devices are recommended to update by heading over to Settings > General > Software update on their respective devices.

Take a look at the complete change log below:

iOS 6.0.2 Software Update

This update contains improvements and bug fixes, including:

? Fixes a bug that could impact Wi-Fi

For information on the security content of this update, please visit this website:

http://support.apple.com/kb/HT1222

Of late, many users took to Apple Support Communities raising complaints related to malfunctioning Wi-Fi connections on the iPhone 5.

?My iPhone 5 connects to Wi-Fi networks and remembers them, but receives absolutely zero data through the network. LTE and 3G no problem... Off to the repair shop (after 3 hours of ownership...),? said one user.

?Called Apple support and the guy said it was the first he heard about it.? Wi-Fi works for like 30 seconds but then all data stops (though it stays connected to the network). I have reset and restored and restarted everything to no avail,? said another user.

However, the release of iOS 6.0.2 is a welcome update for many such users as it is expected to iron out issues affecting the Wi-Fi connectivity.

Macrumors has reported that many users have been facing difficulties when checking for over-the-air updates. If you are also experiencing the same issue, plug your device into iTunes and click ?Check for Update? to get the latest iOS version.

Apple released iOS 6.0.1 update Nov. 1, fixing the virtual keyboard glitch, resolving the issue that caused the camera flash to be turned on constantly and improving the Wi-Fi reception.

The public release of iOS 6.1 is expected sometime around January 2013. New features in iOS 6.1 would include ?enhancements to Siri on compatible devices, an improvement on the way Passbook deals with boarding passes and some are even touting improvements to battery life across the board,? Redmond Pie has reported.

If you?d like to download the iOS 6.0.2 images directly, below are the official download links for the update from Apple:

- iPhone 5 (A1428)

- iPhone 5 (A1429)

- iPad mini Wi-Fi

- iPad mini GSM

- iPad mini CDMA

Source: http://www.ibtimes.com/apple-releases-ios-602-software-update-iphone-5-ipad-mini-fix-wi-fi-bug-download-links-949820

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DealBook: Chinese Companies Head For the Exit

HONG KONG?Fed up with slumping share prices, prickly regulators and aggressive short sellers, an increasing number of Chinese companies listed on American stock exchanges are heading for the exits.

The most recent case is also the biggest yet. On Wednesday, the directors of Focus Media Holdings, a display advertising company based in Shanghai, whose shares had come under attack by short-sellers, said they had accepted a sweetened $3.7 billion privatization bid from a buyout group that included the American private equity giant Carlyle Group, several Chinese private equity firms and the company?s chairman.

The deal would delist the company from Nasdaq. It includes $1.5 billion in debt financing from a consortium of Wall Street banks and mainly state-owned Chinese lenders and would rank as China?s biggest-ever leveraged buyout. Pending shareholders? approval, the company expects the transaction to close in the second quarter of next year.

Including the Focus Media deal, which was first announced in August, Chinese companies began a record $5.8 billion worth of privatization bids in the first nine months of the year, according to the data provider Dealogic. That was a 42 percent increase from the same period a year earlier, and proposed Chinese delistings accounted for a record 16 percent of such transactions globally during the period, up from 6 percent a year earlier.

??A lot of Chinese entrepreneurs want out of the U.S. markets. Share prices are depressed, and there are a lot of these deals in the pipeline,?? said David Brown, greater China private equity practice leader at the auditing firm PricewaterhouseCoopers.

Valuations of companies from China that are listed in the United States have come under pressure in recent years after a wave of allegations of fraud and other accounting scandals. The Securities and Exchange Commission has deregistered the securities of nearly 50 China-based companies and has filed about 40 related fraud cases.

At the same time, a cross-border regulatory dispute over auditing procedures for Chinese companies listed in the United States escalated this month, when the S.E.C. charged the Chinese affiliates of the world?s four biggest accounting companies with violating securities law for failing to turn over documents related to their auditing work on businesses in China.

The standoff between United States and Chinese regulators over the auditing issue has raised concerns among multinational corporations that operate in both countries.

??Failure to reach an agreement will create regulatory dead zones that harm investors and businesses,?? the United States Chamber of Commerce said last week in a letter to securities regulators in Beijing and Washington. ??The threat of retaliatory actions by regulators, on both sides of the Pacific, may create a regulatory protectionism that will harm both economies.??

Source: http://dealbook.nytimes.com/2012/12/20/chinese-companies-head-for-the-exit/?partner=rss&emc=rss

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Ex-National Lampoon CEO Too Poor to Appeal Conviction, Sentence

By Jacqueline Palank

Timothy Durham, who is appealing his conviction on charges that he stole investor funds and blew them on classic cars, expensive homes, a private jet and country-club dues, now cites his own poverty as the reason he can?t afford the costs of that appeal.

?I am not able to pay an attorney for this appeal,? Durham wrote in a new federal court filing in his criminal case (h/t Associated Press). The former chief executive of National Lampoon and now-bankrupt Fair Finance Co. also swore in the filing that, ?because of my poverty,? he cannot pay the filing fees for his appeal.

Durham, who has been incarcerated since his June conviction, said he hasn?t earned any money in the past year. He was arrested in March 2011 on charges that he and colleagues pocketed the money of investors in Fair Finance, cheating them out of some $200 million.

According to the filing, Durham stopped receiving paychecks from National Lampoon in June 2011. (He previously grossed $16,660 per month.) His home is in foreclosure, he wrote, and all of his assets either are subject to criminal restitution or have been targeted by the bankruptcy trustee winding down Fair Finance.

Fair Finance sold interest-bearing certificates to investors and used the funds raised through those sales to buy consumer-finance contracts at a discount. According to prosecutors, Durham and two other executives, James F. Cochran and Rick D. Snow, pocketed investors? money and diverted it to companies under their control as well as into their own bank accounts. They lived the high life, accumulating multiple homes, a private jet, a yacht and several dozen classic and exotic cars.

Court papers show that Durham, 50 years old, was later found guilty of 12 counts of wire and securities fraud as well as conspiracy to commit wire and securities fraud. On Nov. 30, he was ordered to pay $202.8 million in restitution and sentenced to 50 years imprisonment; Durham filed his appeal from Cell 240 in the federal prison in Leitchfield, Ky.

Snow, 49 years old, and Cochran, 57 years old, were each found guilty of some counts and not guilty of others, earning Snow a 10-year prison sentence and Cochran 25 years. Cochran is appealing his conviction.

Write to Jacqueline Palank at jacqueline.palank@dowjones.com.

Source: http://blogs.wsj.com/bankruptcy/2012/12/18/ex-national-lampoon-ceo-too-poor-to-appeal-conviction-sentence/

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Technorati Ranks Firmology as One of the Top 100 Small Business ...

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We?re proud to announce that?Technorati?has ranked?Firmology?as one of the Top 100 Small Business Blogs and News Sites on the entire web!

Technorati is the?preeminent?and world?s largest blog search engine and directory,?measuring a blog?s influence within the blogosphere and its subject category. While it?s every publisher?s dream to be ranked within the Technorati Top 100, you have to start somewhere.

When we first noticed an increase in traffic coming from Technorati, we were ranked #32 out of 23,571 small business news sites & blogs on the web! While the rankings change daily and we?ve bounced all over the place within the Top 100 since making the list, the thought is just mind-boggling as it ranks Firmology amongst small business industry heavyweights such as Inc, Social Media Examiner, Small Business Trends, The Sales Lion and other amazing sites.

As we mentioned on Thanksgiving, we owe our success to Firmology readers!

Without you, there would be no Firmology. It?s not easy to run any business and it?s the same for our site. There are ups and there are downs, but we feel passionate about helping small businesses innovate and grow their business through technology.

We?re excited to keep going and stay on the list forever, but our next goal is to break Technorati?s Top 100 Business list. We currently rank #247 of?33,687 business news sites and blogs on the web, which is pretty awesome as well.

To that end, here?s how our readers can get involved:

Our fellow small business owners:

We want to hear from you and feature your small business on our site. We?re looking for?innovative products and businesses for a new series launching soon, so send us your?innovation stories. Additionally, we?re searching for business owners to feature on our?How I Power My Business?series.

Tech companies/startups:

We?re on the hunt for the latest news, features?and emerging small business tech startups for our SMB Startup Watch series.

Writers:

We?re looking for small business owners and professionals, technology industry professionals, tech enthusiasts and innovators who are passionate about their views and want to share insight with one another. Write for Firmology.

Advertisers:

While we may not have that much traffic yet, we quadrupled our traffic year over year, so get in early and invest in a fast-growing media startup in 2013. ?Advertise on Firmology.

For more small business resources, follow?Firmology?on?Twitter?or?LinkedIn.

To contact the writer on this story: Philip Nowak in Chicago at philip.nowak@firmology.com. Please?contact us?if you?d like to?submit a small business innovation story or small business tech startup, product or service.

Written by Philip Nowak

Philip Nowak is the founder of Firmology, a?news?and information media company focused on helping small businesses grow through?small business technology?and innovation.?You can find Philip on?Google+,?Twitter?and?LinkedIn.

Source: http://www.firmology.com/2012/12/18/technorati-ranks-firmology-as-one-of-the-top-100-small-business-blogs-and-news-sites-on-the-web/

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Holiday Pets | Steve Harvey Show

	Princess Princess is a gorgeous 9-month-old yellow Labrador Retriever. Princess is ready for brisk temperatures & snow in her down jacket and scarf. She loves to run around and play, and would make a great addition to a home with children. She is smart and is eager to learn, especially with treats, but since Princess is a baby, she?ll need enough space to run and grow, and an owner who has the time and patience to train a puppy. Click here to adopt a pet.
	Flanker Flanker?s a charming 2-year-old Pointer who?s the teacher?s pet and a quick learner. Flanker?s dressed in Hanukkah attire. He?s searching for a patient owner with a relaxed lifestyle. He would also love a family who will slowly help him come out of his shell. With a little love, Flanker will blossom into a wonderful friend for life. Click here adopt a pet.
	Wyatt Wyatt is a 2-year-old Cockapoo Mix ? a combination of a cocker spaniel & a poodle. He?s dressed as Santa Clause. Wyatt always has belly rubs on the brain. After a rough start at life, he?s is now looking forward to play and sleep in his warm forever home. Click here to adopt a pet.
	Pearl Pearl is a 1-year-old Poodle who is gentle and loving and happy to be close to you all the time. She?s dressed as Mrs. Claus. Pearl is sweet likely to quickly bond with her new owner. Click here to adopt a pet.
	Cranberry Cranberry is a 1-year-old Shih Tzu mix. She?s dressed in formal attire to ring in the new year. She?s sweet, gentle and cuddly. While she loves to be petted and held, she also enjoys long walks outside to sniff out the neighborhood. Click here to adopt a pet.
	Buddy Buddy is a 1-year-old Jack Russell Terrier dressed in a tuxedo for New Year?s Eve. He?s one of many purebreds you can find at shelters. Buddy is spunky and really loves life. He plays catch and he needs an energetic family who loves to play and be outdoors. He?s ready to meet his forever family and give them never- ending unconditional love. Click here to adopt a pet.

Special thanks to the following boutiques for the holiday clothing featured on the pets: Tails in the City and Barker & Meowsky.

Source: http://www.steveharveytv.com/holiday-pets/

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Foreign investment in China falls

China's foreign direct investment fell 5.4% in November from a year earlier, the government said, while an official warned that increasing international competition presents a challenge to China's ability to keep foreign investment.

• Breaking industry news & commentary
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Source: http://www.efinancialnews.com/story/2012-12-18/foreign-direct-investment-china?mod=rss-assetmanagement

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Chavez allies sweep Venezuela gubernatorial vote

CARACAS, Venezuela (AP) ? President Hugo Chavez's allies won a sweeping victory in Venezuela's gubernatorial elections Sunday, capturing a large majority of states and showing their socialist party still has muscle even as cancer has put the socialist leader's future in question.

The ruling party won at least 19 of 23 states, according to preliminary results. Opposition leader Henrique Capriles held on for a re-election win in Miranda state, one of three opposition candidates declared winners.

Capriles lost to Chavez in the country's October election, and his re-election Sunday will allow him to cement his position as Venezuela's dominant opposition leader, even as other opposition candidates floundered. But the loss of ground by the opposition also raises tough questions for government adversaries as they prepare for the possibility of new presidential elections if cancer cuts short Chavez's tenure.

Going into the vote, the opposition had held the governorships in eight states, and it lost in five of those states according to the results announced by National Electoral Council President Tibisay Lucena.

Jorge Rodriguez, campaign manager for the pro-Chavez camp, hailed the victory saying it represented "the map painted red" ? the color of Chavez's socialist party.

"It really does underscore the fact that Chavismo really can survive, at least at the regional level, without Chavez," said Miguel Tinker Salas, a Latin American studies professor at Pomona College in Claremont, California.

"The reality is that the Chavistas today proved that their movement is institutionalized enough to sustain itself and to win statehouses in almost 90 percent of Venezuela."

He said he faulted the opposition for its lack of organization and lack of a clear message.

The vote was the first time in Chavez's nearly 14-year-old presidency that he has been unable to actively campaign. He hasn't spoken publicly since undergoing cancer surgery on Tuesday in Cuba.

The strong showing by pro-Chavez candidates could help them deepen his socialist policies, including a drive to fortify grass-roots citizen councils that are directly funded by the central government.

Capriles beat Elias Jaua, Chavez's former vice president, to win Miranda state, which includes part of the capital of Caracas. His supporters celebrated shouting with their hands in the air while fireworks exploded overhead.

The 53 percent voter turnout was considerably lower than the more than 80 percent who cast ballots in October's presidential vote, when Chavez won another six-year term.

There were some complaints of improper campaigning during the vote. While voting was under way, Vice President Nicolas Maduro urged supporters to vote for Chavez's allies, while opponents called his remarks a violation of electoral rules.

Speaking at a news conference, Maduro implored voters: "Let's not fail Chavez." He addressed those who hadn't cast ballots yet, saying "let's not make a bad impression with our commander Chavez."

Opposition leader Ramon Guillermo Aveledo said his remarks violated a prohibition on campaigning on election day, and called for the National Electoral Council to take action. Vicente Diaz, a member of the council, called Maduro's comments inappropriate and he would take up the matter with the council.

The elections were seen as an important dry run for new presidential elections if cancer prevents Chavez from continuing. His supporters and opponents alike raised the possibility of a new presidential vote soon as they stood chatting while waiting to vote.

Chavez is due to be sworn in for another six-year term on Jan. 10. But if his condition forces him to step down, Venezuela's constitution requires that new presidential elections be called promptly and held within 30 days.

Chavez said before undergoing the surgery that if he's unable to continue, Maduro should take his place and run for president.

Tinker Salas said that their showing in the gubernatorial races "means the government forces will have a strong state machinery in the event of a national election."

___

Associated Press writers Frank Bajak in Lima, Peru, and Vivian Sequera in Caracas contributed to this report.

Source: http://news.yahoo.com/chavez-allies-sweep-venezuela-gubernatorial-vote-021625481.html

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Bunnie Huang building an open, ARM-based laptop, might even sell you one if you ask nicely

How do you follow-up creating Chumby, exposing illicit microSD card production and building an open-source radiation detector? If you answered "go to Disneyland," then you aren't Andrew "Bunnie" Huang -- who is now designing and building his very own laptop. Powered by an ARM Cortex A9 and running Linux, the hardware is NDA-free and as open as he can make it, with documents already online for you to study. He's expecting to finish validation and testing in the next few months, and may even offer a few for sale on Kickstarter -- although he does warn that it won't come cheap, so if you're looking for a machine to noodle around on, just get an EeePC.

Filed under: Laptops

Comments

Via: Boing Boing

Source: Bunnie Huang

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/pY2sKxGTg-g/

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Foods To Cure Hepatitis ? Best Diet For Hepatitis

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Rating: 5.0/5 (1 vote cast)

Liver is an important organ in the body. It filters the blood passing through it and eliminates the toxins from it. Hepatitis damages the liver and impairs its ability to eliminate the toxins. So, you have to be careful about what foods you consume. Here are some dietary tips to help you deal with hepatitis.

General Advice

Just because you have hepatitis, it does not mean that your dietary requirements are drastically altered. You would still need the right amount of calories, carbohydrates, protein, fat, vitamins and minerals. However, the foods from which you should try to get them and their quantity can be different. Do not eat large meals at any time.

Try to eat 5-7 small meals a day, including snacks in the evening. This will reduce the burden on the liver. Eating small meals also compensates for the reduced ability of the liver to store glucose in the form of glycogen, allowing it to store small amounts with each meal.

Foods to Take

Fruits and Vegetables

Fruits and vegetables have many nutrients and also antioxidants. Antioxidants will boost your immune system and help you fight the disease. Try to choose fresh fruits from various coloured groups. Vegetables that are helpful are green leafy vegetables, broccoli and tomatoes.

Foods Rich in Omega-3 Fatty Acids

Omega-3 fatty acids reduce the inflammation of liver. Body cannot synthesise them on its own. Fatty fish like tuna, mackerel, sardines and salmon are rich in omega-3 fatty acids. Other foods rich in them are flax seeds and their oil, canola oil and walnuts.

Complex Carbohydrates

Starchy vegetables and whole grains are complex carbohydrates that provide plant-based chemicals called phytonutrients. Phytonutrients help fight the disease. Whole grains are brown rice, whole-grain bread, rye and oats. Starchy vegetables are sweet potatoes and winter squash.

Foods Adequate in Protein

Protein helps in repair and maintenance of the tissues of the body, so it will heal the liver cells that are damaged. Milk, cheese, yogurt, meat, eggs, soy, dried beans and nuts contain good amount of protein. Consume them in moderate quantities.

Meals Low in Fat

Liver produces bile, which aids in the digestion of fats. In hepatitis, since the liver is damaged, the ability to digest fats is impaired. So, your diet should be low in fat.

Vitamin and Mineral Supplements

Food is the best way to get vitamins and minerals. If you are consuming a balanced diet as above, you will get them in right amounts. But, a multivitamin and mineral supplement may be helpful.

Also Read

Hepatitis Liver Causes, Symptoms And Management
Hepatitis C Symptoms
Important Types Of Hepatitis

Foods to Avoid

Fatty Foods

Fast foods, fried foods, and processed products like crackers and cookies are high in fat, and should be avoided. Limit your consumption of animal fat, which is found in poultry and meat.

Salty Foods

Too much salt can lead to excess fluid retention in the body. So, restrict its intake. Foods high in salt are canned soups, chips and processed foods like crackers.

Sugary Foods

The many forms of sugar are sucrose, fructose, honey, corn syrup and maple syrup. Sugary foods provide mainly calories and little else. So, avoid desserts, pastries and sweets.

Alcohol

Even in healthy people, alcohol acts as a toxin to the liver, so you can imagine how harmful it can be when you have a diseased liver. Avoid alcohol altogether.

Best Diet For Hepatitis, 5.0 out of 5 based on 1 rating

Source: https://www.ayushveda.com/magazine/best-diet-for-hepatitis/

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lern2play Resources and Information. This website is for sale!

By using our site, you consent to this privacy policy: This website allows third-party advertising companies for the purpose of reporting website traffic, statistics, advertisements, "click-throughs" and/or other activities to use Cookies and /or Web Beacons and other monitoring technologies to serve ads and to compile anonymous statistics about you when you visit this website. Cookies are small text files stored on your local internet browser cache. A Web Beacon is an often-transparent graphic image, usually no larger than 1 pixel x 1 pixel that is placed on a Web site. Both are created for the main purpose of helping your browser process the special features of websites that use Cookies or Web Beacons. The gathered information about your visits to this and other websites are used by these third party companies in order to provide advertisements about goods and services of interest to you. The information do not include any personal data like your name, address, email address, or telephone number. If you would like more information about this practice and to know your choices about not having this information used by these companies, click here.

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Christmas Card Craft Projects: Easy Ways to Recycle Old Cards, Part 1

If you have ever sent or received Christmas Cards, you know how hard it is to throw away some of these fun treasures.

? ? ?I have a box filled with both old Christmas cards; as well as some left over cards from years gone by. ?I decided to come up with some easy craft project that my kids could do to re-use these cards this year.
We located some?simple craft supplies (scissors, glue, dimensional tape, glue dots, glitter, etc.) that we had around the house.

Above are some of the new Christi Friesen Glitzy Glitters. ?I love the different textures in these glitters, because they really reflect light a lot and make craft projects a bit more fun. Hint: when working with glitter,?I recommend using the Perfect Printing Pouch which keeps
the glitter from sticking to surfaces. ?By using it, the kids were able to control where the glitter adhered to on the card. ?It is a handy tool when working with glitter or embossing powders.
? ? ?I then took a couple of cards that I had duplicates of and had the kids cut out some of the elements.

Then they added glitter to parts of the card.

They used the dimensional tape to attach the snowman cut out to the card base. ?The tape gives the card a bit more dimension and the snowman a bit of a shadow. ?In the snowman card below, the kids cut out the hat, the scarf and the red gift box.

They added some highlights with glitter, as well as some rhinestones to make the card pop. ?As you can see this is super easy and just requires a little drying time (for the glitter). ?Tomorrow I will post another easy Christmas card recycling project.

Disclosure

Source: http://keepcalmandcrafton.blogspot.com/2012/12/christmas-card-craft-projects-easy-ways.html

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President's pot comments prompts call for policy

SAN FRANCISCO (AP) ? Medical marijuana advocates are taking some solace from President Obama's statement that prosecuting individual users in Colorado and Washington is not a priority, but they want assurances that federal crackdowns on big pot dispensaries will end in California and other states.

Local and state officials, meanwhile, called on the administration to clarify its enforcement policy in states with marijuana laws.

Obama said federal authorities would leave alone individual users in Colorado and Washington, states that legalized recreational marijuana use.

Still, federal officials said they will continue to try to shut down big commercial pot operations, whether they operate under state medical marijuana laws or not. The federal government is planning to soon release policies for dealing with marijuana in Colorado and Washington, where pot is now legal under state law.

Source: http://news.yahoo.com/presidents-pot-comments-prompts-call-policy-074618080--finance.html

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American Bulldog - Oliver - Large - Young - Male - Dog - Pensacola ...

American Bulldog - Oliver - Large - Young - Male - Dog

Please understand we must conduct home visits in order for any dogs to be adopted. This is merely for the safety of these rescues. All animals are $75.00 - 150.00. Some dogs require fenced in yards, please feel free to ask any of our volunteers if the animal you're interested in requires a fenced in yard.
Please call 850-968-3260 for information on any of the animals you see listed with the JHS (Jr. Humane Society)

Mr. Oliver has a micro chip and is fixed already. Wonderful with children and would make an amazing family dog. He needs space to run around and he loves being around other dogs.
$75 adoption fee
850-968-3260
Pensacola area

The Junior Humane Society is a non-profit, all volunteer, animal rescue group. For over 24 years, we have taken in owner released pets so they won't be taken to the pound/animal shelter. All animals waiting for adoption are placed in foster homes. Before placing the animal in a permanent home we provide all necessary vet care, including but not limited to shots, spaying and neutering.

CHARACTERISTICS:
Breed: American Bulldog
Size: Large
Petfinder ID: 24868897

ADDITIONAL INFO:
Pet has been spayed/neutered

CONTACT:
United Humanitarians/Jr. Humane Society | Cantonment, FL | 850-968-3260

For additional information, reply to this ad or see: http://www.petfinder.com/petnote/displaypet.cgi?petid=24868897

Brought to you by Petfinder.com

Source: http://pensacola.ebayclassifieds.com/dogs-puppies/cantonment/american-bulldog-oliver-large-young-male-dog/?ad=25079154

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Pet Dogs | Get The Best Fit Dog Kennel For Your Pet | Puppy Dog

Saturday, December 15th, 2012

However, some of the people are thinking that putting a dog inside a dog kennel is not inhumane.There are so many dog kennels are available in the present market, which are offering excellent sense of comfort, especially if you are using this kennel from the young age of the dog.If you are doing like this, then the dog will think that it as the dogs home and it the place where it can go to relax and unwind. However, there are so many varieties of dog kennels are available for your needs and in these days, all of these dog kennels are treated as a modern remake of the traditional doghouse.

Some of the pet dogs are interested to spend their time outside.For them, you need to purchase outdoor dog kennels. wooden dog kennels are a good choice for a family who would like their pet to have a comfortable, safe, and stylish home.There are a variety of different features to choose from, including color, whether it will be inside or outside your house, and also the type of wood you may prefer. If you want to along with your dog, then you need to have a portable dog kennel for you. However, among all of those kennels, chain link dog kennels are best one regarding dog safety and security.The biggest advantage with these chain link dog kennels is you can build your own dog kennel.

You need to consider above things before purchasing a dog kennel, and also you need to consider about the indoor or out door kennels. All of these kennels are readily available for you.Finally, there are some well established and experienced manufactures of the dog kennels and dog panels are selling through the internet. For more information and details, please visit their valuable web site.

Leave a Reply

Source: http://dog.petsgo.org/pet-dogs-get-the-best-fit-dog-kennel-for-your-pet/

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On Immigration, a Dissent - Ricochet.com

I just listened to the flagship podcast (Rob shamed me into becoming a member, after I freeloaded during the days before it went behind the paywall) and I wanted to register a dissent from something Peter said about immigration. He said something to the effect that large-scale immigration was ?over? or ?finished? ? implying that addressing the status of illegal aliens living here would now be easier.

The report he was relying on,?from Pew, said that net migration from Mexico was zero in the 2005-2010 period ? i.e., there was still a significant amount of immigration from Mexico (almost all of it illegal), but roughly the same number of Mexicans already living here left, resulting in no net change. This is a real finding, and it owes to both the state of the economy and to better law enforcement ? my research director reached a?similar conclusion. But there are lots of problems with drawing policy conclusions from that:

1. Pew counted the US-born, US-citizen children in Mexican immigrant families as part of the ?Mexican? outflow ? but, of course, they?re not immigrants, so net immigration was still positive.

2.?Our goal should be?more?illegal immigrants leaving than coming in, so a net level of zero is a move in the right direction, but is hardly reaching the goal. (?Mexican immigrant? and ?illegal immigrant? are obviously not the same thing, but they?re closely related ? 60 percent of illegal aliens are from Mexico and virtually all Mexican immigrants either are, or were at one point, illegal.)

3. Most immigration is legal ? 1.1 million a year, and it never goes down ? and the problems created by mass?illegal?immigration?aren?t really that different?from the ones created by mass?legal?immigration.

4. The real slowdown in illegal immigration has almost certainly already ended, with numbers already climbing again.

5. There are 5 billion people in the world poorer than the average Mexican, so immigration is not something we?re ever going to ?solve? ? thus we can never escape having to make decisions about how much we want, how we pick people, and how we will enforce the law to prevent the admission (or effect the removal) of the millions who want to come but don?t meet our criteria.

I addressed this ?immigration as yesterday?s news? meme in a piece earlier this year for?The National Interest. My lead was from a January?New York Times?op-ed?that began: ?The immigration crisis that has roiled American politics for decades has faded into history.?

Would that it were true.

Source: http://ricochet.com/main-feed/On-Immigration-a-Dissent

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Carriers of gene variant appear less likely to develop heart disease

Dec. 14, 2012 ? Scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University have discovered a new gene mechanism that appears to regulate triglyceride levels. This pathway may protect carriers of a gene variant against cardiovascular disease, especially among those with greater intakes of polyunsaturated fat (PUFA).

The findings, published online this week in the American Journal of Human Genetics, contribute to research efforts to develop gene-specific diets that could potentially improve general health and complement chronic disease prevention and treatment.

The authors analyzed data from more than 27,000 men and women enrolled in ten epidemiological studies conducted in the United States and Europe that comprise the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Focusing on the Single Nucleotide Polymorphism (SNP) rs13702, they observed that a type of small RNA known as microRNA (miR), impacts production of lipoprotein lipase (LPL), an enzyme that mediates the metabolism of circulating triglycerides.

"We saw no miR activity in carriers of the gene variant," said senior author Jos? M. Ordov?s, senior scientist and director of the Nutritional Genomics Laboratory at the HNRCA at Tufts University. "In the majority of the subjects the miR appeared to attach to the messenger RNA (mRNA), slowing down the manufacturing of LPL. Without that interference, people with the variant would presumably have more LPL available to breakdown excess triglycerides and prevent them from being deposited in the arteries, which could eventually lead to atherosclerosis and other cardiovascular diseases."

The authors also noted lower triglyceride levels and higher concentrations of high-density lipoprotein (HDL) cholesterol, the so-called "healthy" cholesterol in association with the gene variant. Furthermore, carriers tended to have even lower triglyceride blood levels if they had higher PUFA intake.

"Based on the data, carriers of the gene variant may be able to further reduce their risk for cardiovascular disease by increasing their PUFA intake," said Kris Richardson, Ph.D., a USDA Agricultural Research Service (ARS) post-doctoral associate in the Nutritional Genomics Laboratory and a recent graduate of the Sackler School of Graduate and Biomedical Sciences at Tufts University. "To build on our observational data, future studies might investigate the effect of treating human cells in culture with PUFA to determine if it will mediate LPL levels through the identified miR."

PUFA, found in foods such as salmon and vegetable oils, is considered a healthier fat. The current U.S. Dietary Guidelines for Americans recommend replacing saturated fats with the more beneficial PUFA and monounsaturated fats whenever possible.

Jos? M. Ordov?s is also a professor at the Friedman School of Nutrition Science and Policy at Tufts University and a member of the Pharmacology & Experimental Therapeutics Faculty at the Sackler School.

This study is supported by grants from USDA and the National Heart, Lung and Blood Institute (NHLBI), and award number P50 HL105185-01. A complete list of funding sources is available in the supplemental data portion of the paper.

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Story Source:

The above story is reprinted from materials provided by Tufts University, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Kris Richardson, Jennifer?A. Nettleton, Noemi Rotllan, Toshiko Tanaka, Caren?E. Smith, Chao-Qiang Lai, Laurence?D. Parnell, Yu-Chi Lee, Jari Lahti, Rozenn?N. Lemaitre, Ani Manichaikul, Margaux Keller, Vera Mikkil?, Julius Ngwa, Frank?J.A. van?Rooij, Christie?M. Ballentyne, Ingrid?B. Borecki, L.?Adrienne Cupples, Melissa Garcia, Albert Hofman, Luigi Ferrucci, Dariush Mozaffarian, Mia-Maria Per?l?, Olli Raitakari, Russell?P. Tracy, Donna?K. Arnett, Stefania Bandinelli, Eric Boerwinkle, Johan?G. Eriksson, Oscar?H. Franco, Mika K?h?nen, Michael Nalls, David?S. Siscovick, Denise?K. Houston, Bruce?M. Psaty, Jorma Viikari, Jacqueline?C.M. Witteman, Mark?O. Goodarzi, Terho Lehtim?ki, Yongmei Liu, M.?Carola Zillikens, Yii-Der?I. Chen, Andr??G. Uitterlinden, Jerome?I. Rotter, Carlos Fernandez-Hernando, Jose?M. Ordovas. Gain-of-Function Lipoprotein Lipase Variant rs13702 Modulates Lipid Traits through Disruption of a MicroRNA-410 Seed Site. The American Journal of Human Genetics, 2012; DOI: 10.1016/j.ajhg.2012.10.020

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/pNboaz6FBRg/121214091359.htm

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